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Purpose: The present study examines the potential uses of Amazon Sailfin Catfish Pterygoplichthys pardalis in wastewater treatment. The main objective is to investigate the efficiency of P. pardalis in the biotreatment of sewage. Methods: The treatment of sewage with P. pardalis was carried out by analyzing the parameters such as total solids, total suspended solids, total dissolved solids, pH, BOD3 30o C and phosphates. The biotreatment efficiency of the fish P. pardalis was studied using different concentrations of sewage (20, 40, 60 and 80%) after 2, 4, 6 and 8 days of treatment. Results: The investigation revealed that after treatment with P. pardalis, the treated sewage had lower values of all the parameters than that of untreated sewage. Conclusion: It can be concluded that P. pardalis is efficient in the remediation of sewage.